Purpose. To demonstrate visually the non-specific character of accumulation of radiolabeled somatostatin analogs.

Materials and methods. We present a case report of renal cell carcinoma progression 17 years after unilateral radical nephrectomy in a 61-year-old patient. Follow-up multi-detector row computed tomography (MDCT) of the chest and abdomen with intravenous contrast enhancement showed  lesion of the pancreatic head with high contrast enhancement. Whole-body planar scintigraphy and single-photon emission computed tomography combined with X-ray computed tomography (SPECT/CT), performed to clarify the nature of the lesion in the pancreas previously detected by MDCT.

Results. Pathological uptake of the radiolabeled analogue of somatostatin 99mTc-HYNIC-TOC was revealed in the pancreas and soft tissues of the shin. Considering patient’s clinical history, these lesions was interpreted as metastatic, which was confirmed during the subsequent morphological examination.

Conclusion. This case report demonstrates the importance of patient's history in differential diagnosis of NET.