Dynamics of CT-picture changes in patients with a critical degree of lung tissue damage caused by the Sars-Cov-2 virus

 

Komissarova K.V. 1,2., Godzenko A.V.1, Rumyantsev J.I. 1, Doroshenko D.A. 1,2,

Gordeev I.G. 1,2, Averkov O.V. 1,2, Vechorko V.I. 1,2

 

It was found that death from coronavirus infection is the more likely, the higher the degree of damage to the lung on the visual scale "CT 0-4". Thus, patients with pulmonary involvement of 75% or more are predictively poor in terms of outcome. Assessment of the influence of the rate of disease progression to CT-4 on mortality and the search for factors affecting this indicator may be of practical importance.

The purpose of this study is comparison of the duration of progression of the CT picture to a critical degree in various "waves" of the pandemic, the search for factors influencing the interval of "debut diseases - CT 4", as well as the assessment of the state of the lung tissue after a total process in a long period of time.

Materials and methods: a retrospective analysis of 708 patients (226 in the first wave, 482 in the second wave), hospitalized at City Clinical Hospital No. 15 and having a critical degree of lung. 25 discharged patients underwent a control CT scan 6 and 12 months after discharge from the hospital.

Results: The study groups were comparable in terms of demographic characteristics and the degree of CT at admission in hospital. When comparing the interval "onset of the disease - detection of CT-4", no significant differences between the "waves" were found (p = 0.372). When assessing the CT-picture in the delayed period, there were no significant differences in the frequency of changes between the groups; an almost complete regression of inflammatory changes was observed. In the study of the entire sample, an increase in the interval "onset of the disease - detection of CT-4" (p = 0.033) was found in men (11 days (7-16)) compared with women for 10 days (6-15), and in discharged patients (12 days (8-18) compared with deaths (10 days (6-15)) (p <0.001). There was a significant reduction in the progression time with increasing age of patients (p = 0.003)

Conclusions: Considering the data obtained on the possible influence of the timing of the progression of the CT picture on the mortality of patients, as well as the results of long-term observation, it is advisable to search for modifiable risk factors for the rapid progression of the disease.

1 - O.M. Filatov City Clinical Hospital №15, Moscow

2 - Pirogov Russian National Research Medical University, Moscow, Russia.

 

Keywords: Sars-Cov2 virus, coronavirus infection pandemic, extremely severe pneumonia, CT-4 pneumonia.

 


Corresponding author: Komissarova K.V. e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript .

 

For citation: Komissarova K.V., Godzenko A.V., Rumyantsev J.I, Doroshenko D.A., Gordeev I.G., Averkov O.V., Vechorko V.I. Dynamics of CT-picture changes in patients with a critical degree of lung tissue damage caused by the SARS-COV-2 virus. REJR 2022; 12(2):13-20. DOI: 10.21569/2222-7415-2022-12-2-13-20.

Received: 03.11.21 Accepted: 13.04.22