Hysterosalpingography is a radiologic procedure that uses contrast media to assess the morphology of the endometrium, uterus, and fallopian tube patency in infertile women and recurrent abortion. HSG procedure can detect abnormalities in the uterine cavity and fallopian tube, which has several advantages, such as safe, easy, useful, and affordable.

Materials and methods. A 32-year-old woman with 2 years of primary infertility, who underwent hysterosalpingography (HSG) to see abnormalities in the uterine cavity and fallopian tubes as one of the causes of her infertility. The subject tells no history of allergy, but she has a history of recurrent vaginal discharge (infection factor).

Results. Gynecological inspection of the external genitalia and in specular organs did not show any abnormalities, but somehow after giving the contrast media the subject feels swollen eyelids, facial edema, shortness of breath, and dryness in the throat and the eyes feel closed after 15 minutes to an hour. The subject gradually improved after 24 hours and 2 days of healing of the eyelids. Based on clinical symptoms, this case is an example of a moderate level of allergy. The subject occurred swelling of the palpebral (eyes area), a feeling of shortness of breath, and dry throat, all were the symptoms of hypersensitivity reaction. Furthermore, the subject's HSG features including type I (immediate) hypersensitivity reaction or anaphylactoid reaction.