Assessment of correlation dependence of clinical and radiology research methods in patients with hemophilical arthroathy

Solodovnikova I.S., Zavadovskaya V.D., Zorkaltsev M.A.

Purpose. To determine the role of magnetic resonance imaging (MRI) in assessing the condition of the joints in patients with hemophilia in the light of new approaches to the treatment and prevention of hemophilic arthropathies.

Materials and methods. A total of 26 people aged 5 to 40 years old with type A hemophilia, a severe form of the disease were studied - a total of 82 joints (knee (n = 45; 54.8%), ankle (n = 14; 17%) ), elbow (n = 19; 23.1%), hip joints (n = 4; 4.8%)). A clinical examination of patients, radiography and MRI of the joints.

Results and discussion. 2 groups of patients were identified, depending on age and therapy. The correlation between the results obtained was assessed by the FISH, HJSH scale for the results of the clinical examination, Pettersson and Denver for the results of X-ray and MRI, respectively. The Denver scale was divided into two components: bone and soft tissue. As a result of the analysis of the obtained correlations, the role of radiography and MRI in assessing the condition of the joints in two groups of patients was determined. A differentiated comparison of bone and soft tissue changes detected during MRI with data from clinical examination and X-ray.

Conclusion. The main manifestations of hemophilic arthropathy in patients of group 1 were signs of secondary osteoarthritis, in patients of group 2, signs of synovitis and bone marrow edema (osteitis). In both groups of patients, a strong correlation was found between the clinical assessment scale and MRI data with a moderate correlation dependence of the clinical status and X-ray data in group 1 and a weak correlation of clinical status and X-ray in group 2. X-ray picture is moderately correlated with osteochondral changes according to MRI data in patients of group 1 and weakly correlated with MRI data in group 2 due to the detection of damage to the articular cartilage, as well as small cysts and erosions exclusively according to MRI data.

Siberian State Medical University.

Tomsk, Russia

 

Keywords: hemophilic arthropathy, hemostatic replacement therapy, X-ray, magnetic resonance imaging, correlation analysis, FISH, HJSH, Pettersson, Denver.


Corresponding author:  Zavadovskaya V.D., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript , Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript

 

For citation: Solodovnikova I.S., Zavadovskaya V.D., Zorkaltsev M.A. Assessment of correlation dependence of clinical and radiology research methods in patients with hemophilical arthroathy. REJR 2019; 9(1):89-101. DOI:10.21569/2222-7415-2019-9-1-89-101.

Received:        04.04.19 Accepted:       16.04.19