Possibilities of application of methods of radionuclide diagnostics in patients with desomorphine dependence.

Babkova A.A., Pasha S.P., Serova N.S.

Purpose. To determine the diagnostic possibilities of radionuclide methods of diagnosis in examination of patients with phosphorus osteonecrosis of the facial skeleton and desomorphine dependence. Materials and methods. The study involved 40 drug-dependent patients with the di-agnosis of "Toxic phosphorus osteonecrosis of the bones of the facial skeleton". In the pre-operative period 18 patients underwent radionuclide diagnosis, including osteoscintigraphy planar and single photon emission computed tomography (SPECT) with the use of radio-pharmaceuticals (RP) 99mTc-perfotech. The analysis of the obtained data was evaluated such factors as the intensity and localization of the radiopharmaceutical (RFP) in the bones of the facial skeleton, the intensity and localization of the radiopharmaceutical in the bones of other parts of the skeleton. All patients underwent operative treatment in the amount of resection of the jaws. 22 patients also underwent radionuclide diagnostics (osteoscintigraphy planar, SPECT) in the postoperative period (9-12 months after surgery). The evaluation criteria of the obtained data were similar to those on preoperative stage. Results. According to the radionuclide diagnostics in the preoperative stage all patients (n=18; 100%) was determined by the increased accumulation of the radiopharmaceutical in the bones of the facial skeleton, also noted a less intense accumulation of the radiophar-maceutical in the other bones of the skeleton: in the area of the body and the handle of the sternum (n=6; 33%) in the clavicle, humerus heads (n=6; 33%), the crests of the iliac bones (n=8; 44%), in the projection of the elbow (n=2; 11%), in the projection of the knee joint (n=4; 22%). At the postoperative stage of the 22 patients (100%) in 12 patients (55%) remained accumulation RFP in the field of facial bones, 4 patients (18%) was noted for the accumulation of the radiopharmaceutical in the local areas of the front segments of the edg-es, less intense – in the area of the body and the handle of the sternum (n=8; 36%) in the clavicle, humerus heads (n=4; 18%), crests of iliac bones (n=8; 36%. ). The results of the analysis of the obtained data were used to determine diagnostic ability of radionuclide diag-nostic methods in the evaluation of patients with phosphorus osteonecrosis of the facial skeleton with desomorphine dependence. Conclusions. Thus, radionuclide diagnostic methods expand and complement the in-formation on the localization and prevalence of osteonecrosis in patients with desomorphine dependence as for the pre - and postoperative stages of treatment.

I.M. Sechenov First Moscow State Medical University. Moscow, Russia.

 

 

 

 

 

Keywords:osteonecrosis, desomorphine, radionuclide diagnosis, bone scan, single photon emission computed tomography.

 

Corresponding author:Babkova A.A., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript

 

For citation: Babkova A.A., Pasha S.P., Serova N.S. Possibilities of application of methods of radionuclide diagnostics in patients with desomorphine dependence. REJR 2017; 7(3):136-143. DOI:10.21569/2222-7415-2017-7-3-136-143

Received: 11.04.2017 Accepted:04.09.2017