The use of 18F-DOPA PET/CT imaging in congenital hyperinsulinism.

: Gubaeva D.N., Melikyan M.A., Ryzhkova D.V., Nikitina I.L.

Congenital hyperinsulinism is the most common cause of hypoglycemia in children. Congenital hyperinsulinism is divided into diffuse, focal and atypical forms. The surgical management for each form of congenital hyperinsulinism is crucially different. Focal form of congenital hyperinsulinism is cured by selective resection of the pathologic area leading to patient`s recovery. Medically unresponsive diffuse form of congenital hyperinsulinism requires the removal of 95-98% of pancreatic tissue, which may result in diabetes mellitus and exocrine pancreas insufficiency. Differential diagnosis of focal and diffuse forms according to clinical and radiological signs is impossible. Conducting with PET/CT with 18F-DOPA is currently the “gold standard” of differential diagnosis between diffuse and focal forms of the disease. This article is a review of scientific papers for last 10 years and dedicated of methodology and diagnostic accuracy of PET/CT with 18F-DOPA in children with congenital hyperinsulinism.

1 - Endocrinology Research Centre. Moscow, Russia. 2 - Federal Almazov North-West Medical Research Centre. St. Petersburg, Russia.

 

 

 

 

 

Keywords:congenital hyperinsulinism, 18F-DOPA, positron emission tomography, PET/CT.

 

Corresponding author:Gubaeva D.N., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript .

 

For citation: : Gubaeva D.N., Melikyan M.A., Ryzhkova D.V., Nikitina I.L. The use of 18F-DOPA PET/CT imaging in congenital hyperinsulinism. REJR. 2017; 7 (3):144-152. DOI:10.21569/2222-7415-2017-7-3-144-152.

Received: 17.05.2017 Accepted:17.07.2017