The value of intramyocardial administration of erythropoietin stimulated autologous bone marrow cells on left ventricular perfusion and function

Chernyavskiy A.M., Minin S.M., Nikitin N.A., Fomichev A.V., Poveshenko O.V., Kareva Yu.V., Tarkova A.R.

Purpose. To investigate the effect of direct revascularization in complex with intramyocardial implantation of autologous bone marrow cells (ABMC) stimulated with erythropoietin on myocardial perfusion and left ventricle function in patients with coronary artery disease (CAD). Materials and methods. Eighteen patients (14 men, 58 ± 6,9 years) with diagnosed CAD were included. Myocardial perfusion and LV function assessed by ECG-gated 99mTc-MIBI single photon emission tomography (SPECT) before and 6 months after surgical treat-ment. Results. The average size of the persistent perfusion defects in patients before sur-gery was 8,5% [3.5, 18.5] of the myocardial area, that indicated to the presence of myocardial infarction zones. The average size of the stress-induced perfusion defects in patients before surgery was 7,0% [6.0, 12.3] of the myocardial area. 6 month after surgical treatment re-vealed a statistically significant improvement of myocardial perfusion and decreasing both persistent perfusion defects area – an average of 6,0% [2,5; 16,5] (p = 0,008), and stress-induced defects area – up to 4.0 % [1, 5, 6.3] (p = 0,05). There was not significant improve-ment of the LV function. Conclusion. According to ECG-gated 99mTc-MIBI SPECT in patients underwent direct myocardial revascularization procedure in combination with intramyocardial injection ABMC stimulated with erythropoietin, there is an improvement of myocardial scar size and stress-induced myocardial ischemia area size, which indicates to the safety and effectiveness of the performed operative intervention.

E.N. Meshalkin National Medical Research Center. Novosibirsk, Russia.

 

 

 

 

 

Keywords:radionuclide imaging, single photon emission computed tomography (SPECT), myocardial perfusion imaging (MPI), coronary artery disease (CAD), stem cells, bone marrow cells; coronary artery bypass grafting (CABG).

 

Corresponding author:Minin S.M., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript

 

For citation:Chernyavskiy A.M., Minin S.M., Nikitin N.A., Fomichev A.V., Poveshenko O.V., Kareva Yu.V., Tarkova A.R. The value of intramyocardial administration of erythropoetin stimulated autologous bone marrow cells on left ventricular perfusion and function. REJR 2018; 8 (1):66-74. DOI:10.21569/2222-7415-2018-8-1-66-74.

Received: 27.11.2017  Accepted: 29.12.2017