Original articles gadolinium deposition in cerebral tissue after intravenous injection of linear type contrast agent

Original articles gadolinium deposition in cerebral tissue after intravenous injection of linear type contrast agent

Syrkashev E.M., Bychenko V.G., Sinitsyn V.E.

P urpose. To estimate degree of gadolinium deposition in brain structures among patients with multiple injections of linear type gadolinium-based contrast agents. Materials and methods. Retrospective study included 197 patients who received more than two studies with Gadodiamidum injection (0.2 ml/kg) from 2008 to 2017. The control group consisted of 7 patients who had performed at least two studies with no contrast agent injec-tion.
1 - V.I. Kulakov National Medical Research center of obstetrics, gynecology and perinatology.
2 - Medical-rehabilitation center Ministry of Healthcare. Moscow, Russia.



Results. Statistical analysis revealed positive correlation between globus palli-dus/thalamus signal intensity ratio and the number of previous studies with contrast injec-tion (r = 0.145, p = 0.042), with time period between the first and the last study (r = 0.222, p = 0.002) and with the age of patients (r = 0.145, p = 0.042). For nuclei dentati/pons ratio posi-tive correlation was revealed only with the number of previous studies with contrast injection (r = 0.172, p = 0.016). Conclusions. High signal intensity in globus pallidus and nuclei dentati on unen-hanced T1-images related with the number of contrast injection.

Keywords: gadolinium deposition, linear type gadolinium-based contrast agent, gadodiamidum, magnet-ic resonance imaging

 

Corresponding author:Syrkashev E.M., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript

 

For citation: Syrkashev E.M., Bychenko V.G., Sinitsyn V.E. Gadolinium deposition in cere-bral tissue after intravenous injection of linear type contrast agent. REJR 2018; 8 (3):113-121. DOI:10.21569/2222-7415-2018-8-3-113-121.

Received: 01.07.18 Accepted:19.07.18