Сardiac CT-based assessment of epicardial adipose tissue distribution and volume in patients with atrial fibrillation in comparison with healthy individuals

Сardiac CT-based assessment of epicardial adipose tissue distribution and volume in patients with atrial fibrillation in comparison with healthy individuals

Nikitin N., Minin S., Losik D., Mikheenko I., Romanov A.

The association between the presence of atrial fibrillation (AF) and an increased epicardial adipose tissue (EAT) volume has been established, linking a certain amount of probable and possible pathophysiologic mechanisms that could contribute to promoting arrhythmogenesis. In the present study, we aimed to assess the reliability of EAT volume measurements on cardiac CT with adjusted thresholds for fat detection and analyze the association of EAT distribution and volume with the clinical presentation in AF patients in comparison with healthy individuals.


Materials and methods. 45 consecutive AF patients (mean age 55.2 ± 10.3 years, mean AF duration 49.0 ± 38.4 months) with different AF patterns scheduled for an initial ablation for AF and 15 healthy individuals (mean age 36.2 ± 12.6 years) without a history or symptoms of cardiovascular diseases were included. The total, as well as periatrial EAT volumes, were obtained on cardiac CT datasets with adjusted thresholds for fat detection.

Results. The mean difference (95% CI) of total EAT between healthy individuals and AF patients were 103 ml (74, 132 ml; p<0.01) and 33.6 ml (24.8, 42.4 ml; p<0.01) for periatrial EAT. Patients with persistent AF had slightly more total EAT volume but did not significantly differ from patients with paroxysmal AF or long-standing persistent AF.

Conclusion. Сardiac CT allows to reliably quantify the volume of EAT. Patients with AF have significantly large EAT volumes compared to individuals without a history of cardiovascular diseases. There is no significant difference in EAT volumes and distribution between patients with different patterns of AF.

Meshalkin National Medical Research Center. Novosibirsk, Russia.

 

Keywords: epicardial adipose tissue, epicardial fat, atrial fibrillation, healthy individuals, computed tomography.

 


Corresponding author:  Nikita Nikitin, e-mail; Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript

 

For citation: Nikitin N., Minin S., Losik D., Mikheenko I., Romanov A. Сardiac CT-based assessment of epicardial adipose tissue distribution and volume in patients with atrial fibrillation in comparison with healthy individuals. REJR 2021; 11(2):122-129. DOI: 10.21569/2222-7415-2021-11-2-122-129.

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Received: 30.03.21 Accepted: 12.05.21