Bobylev D.A.1, Chekhonatskaya M.L.1, Rossolovsky A.N.1, Kryuchkov I.A.1,

Kondratyeva O.A.1, Nikolenko V.N.2.3, Zakharova N.B.1, Ponukalin A.N.1,


Chekhonatsky I.A.4, Chairkin I.N.2


To compare the diagnostic capabilities of diffusion-weighted magnetic resonance imaging (DVI-MRI) and magnetic resonance imaging with dynamic contrast enhancement (DCE-MRI) in the differentiation of muscle invasive (MIBC) and non-invasive bladder cancer (NIBC).

Materials and methods. The study involved 30 patients with bladder cancer. All patients underwent complex of clinical, laboratory and radiological diagnostics, included magnetic resonance imaging with dynamic contrast enhancement and diffusion-weighted magnetic resonance imaging.

Results. Histopathological examination revealed NIBC in 17 cases (56.7%) and MIBC in 13 (43.3%) cases. In DCE-MRI non-invasive bladder cancer was in 21 (70%) cases and in 9 (30%) muscle-invasive bladder cancer, according to DVI-MRI, NIBC was found in 20 (66.7%) cases and MIBC in 10 (33.3%) cases.

Conclusion. Magnetic resonance imaging with dynamic contrast enhancement, as well as diffusion-weighted magnetic resonance imaging, showed high accuracy of differentiation of non-invasive bladder cancer and muscle-invasive bladder cancer.


1 - V.I. Razumovsky Saratov State Medical University.

Saratov, Russia.

2 - I.M. Sechenov First Moscow State Medical University (Sechenov University).

Moscow, Russia.

3 - Lomonosov Moscow State University.

Moscow, Russia.

4 - Russian Medical Academy of Postgraduate Education.


Moscow, Russia.

Keywords: bladder cancer, magnetic resonance imaging, dynamic contrast enhancement, diffusion-weighted imaging.

Corresponding author: Bobylev D.A., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript

For citation: Bobylev D.A., Chekhonatskaya M.L., Rossolovsky A.N., Kryuchkov I.A., Kondratyeva O.A., Nikolenko V.N., Zakharova N.B., Ponukalin A.N., Chekhonatsky I.A., Chairkin I.N. Comparative analysis of diffusion-weighted and dynamic contrast-enhanced magnetic resonance imaging in differentiation of muscle invasive and non-invasive bladder cancer. REJR 2020; 10(2):148-151. DOI:10.21569/2222-7415-2020-10-2-148-151.



Received:       06.04.20 Accepted:     19.06.20

Exploring the possibilities of Ultrasonic Shear Wave Elastography (SWE) in controlling the formation of bone calluses at different stages of its development.

Material and methods. A study of 51 patients (29 men, 22 women from 17 to 65 years) with fractures of long tubular bones of the upper and lower limbs was conducted. Ultrasound tests were performed on the SuperSonic Aixplorer (France) device with an assessment of tissue stiffness in the kPa and the use of multifrequency probes 2-15 MHz. In the area of the fracture scanned bone corn, surrounding soft tissues and vessels, excluded interposition. The formation of bone calluses was studied at different stages of its development, from 0-7 days to 6 months.

Results. According to the SWE, the most intensive increase in bone calluses is in the first 1.5 months after the fracture, followed by the build-up of bone calluses. For each stage of bone callos formation determined sensitivity, specificity of the method of SWE.

Discussion. The use of the SWE method to control the formation of bone calluses is possible from the first days after bone fracture. The stiffness of bone calluses at SWE is determined in the kPa. Ultrasound also allows you to study the condition of bone fragments, surrounding tissues and vessels. Conducting ultrasound with the use of SWE, dopplerography allows in dynamics to trace the formation of bone calluses in all three stages of its development.

Conclusion. SWE wave allows to determine the stiffness of the bone calluses in the dynamics, starting from the first days after the fracture and to its complete formation. SWE implements a new approach to assess the stiffness of bone calluses, which allows to get accurate quantitative results in real time. The sensitivity and specificity of the SWE in determining the stiffness of bone calluses is highest in the first – connective tissue stage of its formation (94% and 90% respectively).