SEMIQUANTITATIVE ANALYSIS OF PET/CT RESULTS IN PATIENTS WITH PROSTHETIC VALVE INFECTIVE ENDOCARDITIS

 

Aslanidis I.P., Pursanova D.M., Mukhortova O.V., Shurupova I.V., Katunina T.A.,

Alexandrova S.A., Muratov R.M., Popov D.A.

Purpose.

To investigate the semi-quantitative assessment of 18F-fluorodeoxyglucose PET/CT in patients with prosthetic valve infectious endocarditis (PV IE) and without it.

Material and methods. The analysis included results of 18F-FDG PET/CT examinations performed in 50 patients with PV – with surgically confirmed IE (n=30) and with malignancies used as control group (n=20). PET/CT results were assessed visually and semi-quantitatively with calculation of parameters of 18F-FDG uptake intensity in the PV area – SUVmax and SUVratio. SUVratio was calculated as SUVmax in the CIED to SUVmean in the reference zone – aortic blood pool and liver parenchyma.

Results. Visual analysis of PET/CT results revealed abnormal 18F-fluorodeoxyglucose uptake in all patients with IE (n=30); in the control group the uptake was normal in all cases (n=20).

In semiquantitative analysis all parameters in the PV zone, SUVmax and two types of SUVratios, were higher in patients with confirmed IE, compared to patients without it (p<0.001).

ROC-curve analysis for thresholds of SUVmax and two types of SUVratios for the diagnosis of PV IE by PET/CT with optimal sensitivity and specificity was determined: SUVmax = 3.35 (86% and 90%, respectively), SUVratio using aorta = 1.95 (89% and 85%), SUVratio using liver = 1.45 (82% and 85%).

Conclusion. According to the obtained data, both visual analysis and semi-quantitative assessment of 18F-fluorodeoxyglucose PET/CT images showed a good diagnostic performance in the detection of PV IE. The optimal parameter for the diagnosis of IE PV is the SUVratio using aorta with threshold of 1.95 (AUC=0.961).

 

A.N. Bakulev Scientific Center for

Cardiovascular Surgery. Moscow, Russia.

Keywords: PET/CT, 18F-FDG, 18F-fluorodeoxyglucose, infectious endocarditis, infection, prosthetic valve, SUVmax, SUVratio.

 


Corresponding author:  Pursanova D.M., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript

 

For citation: Aslanidis I.P., Pursanova D.M., Mukhortova O.V., Shurupova I.V., Katunina T.A., Alexandrova S.A., Muratov R.M., Popov D.A. Semiquantitative analysis of PET/CT results in patients with prosthetic valve infective endocarditis. REJR 2021; 11(1):125-136. DOI: 10.21569/2222-7415-2021-11-1-125-136.

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Received:       04.09.20 Accepted:     04.02.21