Muravleva A.V., Chernov V.I., Dudnikova E.A., Simolina E.I., Vysockaja V.V., Lukina N.M.,

Ribina A.N., Goldberg A.V. , Tabakaev S.A.

Purpose. To demonstrate a clinical case using single-photon emission computed tomography (SPECT) with a new radiopharmaceutical (RP) "99mTc-1-thio-D glucose" (99mTc-TG) for managing a patient with a verified diagnosis of Hodgkin's lymphoma.

Material and methods. To assess the disease stage the Hodgkin's lymphoma patient was underwent computed tomography with intravenous contrast, SPECT/CT with 99mTc-TG and magnetic resonance imaging. Follow-up examination at the end of treatment included 18F-FDG PET/CT.

Results. A comprehensive examination of the patient using 99mTc-TG SPECT made it possible to diagnose  bone lesion  in the head of the left humerus caused by Hodgkin's lymphoma, while the standard examination method (computed tomography with bolus intravenous contrast enhancement), in this case, was not informative. The SPECT results were in complete agreement with the data of magnetic resonance imaging.

Discussion. The possibility of modern nuclear medicine methods in staging malignant lymphomas has been demonstrated. Single-photon emission computed tomography using an innovative radiopharmaceutical based on a glucose derivative labeled with technetium-99m "99mTc-1-thioD-glucose" made it possible to visualize a metabolically active tumor. The focus of lymphoma in the head of the humerus revealed by SPECT/CT influenced the staging of the process, and the treatment program was adjusted accordingly. Taking into account the problem of providing the regions of the Russian Federation with PET/CT equipment, the complexity of the technological process of RP synthesis, this diagnostic method can be a good alternative to the standard 18F-FDG PET/CT.

Conclusion. Thus, SPECT with a new domestic radiopharmaceutical 99mTc-TG has great potential for metabolic imaging of Hodgkin's lymphoma for staging of the disease.


Tomsk National Research Medical Center Russian Academy of Sciences. Tomsk, Russia.

Keywords: SPECT, 99mTc-1-thio-D glucose, Hodgkin's lymphoma.


Corresponding author:  Muravleva A.V., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript


For citation: Muravleva A.V., Chernov V.I., Dudnikova E.A., Simolina E.I., Vysockaja V.V., Lukina N.M., Ribina A.N., Goldberg A.V., Tabakaev S.A. Metabolic single-photon emission computed tomography with "99mTc-1-thio-D-glucose" – new possibilities for hodgkin's lymphoma staging. REJR 2021; 11(3):171-177. DOI: 10.21569/2222-7415-2021-11-3-171-177.

Received:        18.05.21 Accepted:       09.09.21