Kondrashin S.A.1, Rustomyan A.V.1, Fomin V.V.1, Arushanyan A.R.2, Koblikov V.V.1,

Arakelyan G.A.1.

To assess the condition of domestic coronary stents with antiproliferative coating at different times after their implantation into the coronary arteries.

Materials and methods. Six patients (men – 4, women – 2) aged from 46 to 72 years (62.5 ± 4.1 years) 4.5-35 months (22.0 ± 4.1 months) after stentimplantion in the coronary arteries optical coherence tomography (OCT) was performed. The state of 15 drug-eluting stents was analyzed – seven "Calypso" ("Angioline", RF), four "Resolute Integrity" ("Stentex" (RF) and 4 "Biomime" ("Meril Life Sciences", India) and one bare metal stent “Sinus” (Angioline, RF). According to OCT data, the cross-sectional area of the stented segment, the presence of smooth muscle proliferation, endothelialization of the stent and the degree of healing of the artery wall after stent implantation, stent lumen loss, stent deformation or malapposition were assessed.

Results. Resolute Integrity stents in 3 out of 4 cases had multiple sections of non-endothelialized strata from 3 to 5 mm in length; therefore, patients with these stents were prolonged with dual antiplatelet therapy. Calypso stents in 6 out of 7 cases completely endothelized, like all Biomime stents. The thickness of the neointima averaged 0.12 mm for the Resolute Integrity stents and 0.20 mm for the Calypso stents. Expansion of all stents was optimal without malapposition, and lumen loss ranged from 2.7% to 34.2% regardless of manufacturer.

Conclusion. According to optical coherent tomography, stents of domestic production ("Calypso" and "Resolute Integrity") do not statistically significantly differ in the degree of endothelization at different times after implantation, are clinically effective and safe when used in patients with coronary artery disease.

1 - I.M. Sechenov First Moscow State Medical University (Sechenov University).

2 – ZAO “Implanta”. Moscow, Russia.

Keywords: optical coherence tomography, drug-eluting stent, stent Calypso, endothelialization, dual antiplatelet therapy.


Corresponding author:  Kondrashin S.A.e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript


For citation: Kondrashin S.A., Rustomyan A.V., Fomin V.V., Arushanyan A.R., Koblikov V.V., Arakelyan G.A. Optical coherence tomography after the implantation of russian-made coronary stents. REJR 2021; 11(4):53-59. DOI: 10.21569/2222-7415-2021-11-4-53-59.

Received:        04.10.21 Accepted:       02.12.21