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THE ROLE OF MAGNETIC RESONANCE IMAGING WITH GADOXETIC ACID IN THE

ASSESSMENT OF THE FUNCTIONAL RESERVE OF THE LIVER

 

Mnatsakanyan M.K.1, Rubtsova N.A.1, Kabanov D.O.1, Nerestyuk Ya.I.1, Sidorov D.V.1,

Petrov L.O.2, Isaeva A.G.2, Kaprin A.D.1,2

 

Post-resection hepatic failure is the most severe complication in modern hepatobiliary surgery, its preoperative prediction remains an urgent and unsolved problem. The article presents a personal experience of using magnetic resonance imaging with gadoxetic acid to assess the functional reserves of the liver in patients with liver tumor lesions who are to undergo surgical treatment.

Purpose. To evaluate the diagnostic efficacy of magnetic resonance imaging with gadoxetic acid in assessing liver function in patients who are planned for surgical treatment in comparison with the "gold standard" - hepatoscintigraphy with Tc-99m-Bromeside (mebrofenin) combined with SPECT-CT.

Materials and methods. The study analyzed the data of 47 patients with primary and secondary tumor lesions of the liver, who underwent MRI with gadoxetic acid and hepatoscintigraphy with Tc-99m-Bromezide combined with SPECT-CT at the preoperative stage. Two quantitative indicators of functFLR and HIU were evaluated, the qualitative indicators of the FLIS system for assessing the functional reserve of the liver in patients who are to undergo surgical treatment in the amount of extensive resection.

Results. According to the results of the statistical analysis, a high correlation of liver function indices functFLR (Pearson's correlation index r 0.5704, p = 0.05), HIU (r = 0.6561, p <0.05), FLIS (r = 0.3611, p = 0.016) with the results hepatoscintigraphy with Tc-99m-Bromezide combined with SPECT-CT (p <0.05). Statistically significant differences were obtained between the groups of patients with Child-Pugh classes of liver dysfunctions A and B; A and C (p <0.05). There was a high correlation between the indicators of liver function FunctFLR, FLIS and hepatoscintigraphy (Tc99m-Bromezide) (p <0.05) with the data of the Child-Pugh scale.

Conclusions. MRI with gadoxetic acid has a high potential in the preoperative assessment of liver function, which in the future can be considered as an alternative method for planning extensive resections.

1 - Kazan State Medical University. Kazan, Russia.

2 - Republican Clinical Hospital. Kazan, Russia.

3 - Sechenov University. Moscow, Russia.

4 - Kazan (Volga Region) Federal University. Kazan, Russia.

 

Keywords: liver function, functional MRI, gadoxetic acid, hepatoscintigraphy with mebrofenin, post-resection liver failure.

 


Corresponding author:  Mnatsakanyan M.K., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript

 

For citation: Mnatsakanyan M.K., Rubtsova N.A., Kabanov D.O., Nerestyuk Ya.I., Sidorov D.V., Petrov L.O., Isaeva A.G., Kaprin A.D. The role of magnetic resonance imaging with gadoxetic acid in the

assessment of the functional reserve of the liver. REJR 2022; 12(1):43-55. DOI: 10.21569/2222-7415-2022-12-1-43-55.

Received:        18.01.22 Accepted:       02.02.22