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POSSIBILITIES OF PERFUSION COMPUTED TOMOGRAPHY IN DIFFUSE LIVER DISEASES

Mezikova E.A., Zavadovskaya V.D., Beloborodova E.V., Dolgalev I.V.,

Tonkih O.S., Rodionova O.V.

Purpose. To evaluate the parameters of perfusion computed tomography (PCT) in diffuse liver diseases as an indirect indicator of its functional state.

Materials and methods. PCT of the liver was performed in 41 patients (22 men, 19 women, mean age 45.5 ± 6.2 years). All patients underwent a biochemical blood test, ultrasound elastography, PCT, the first group consisted of patients with hepatitis –19, the second – 22 patients with cirrhosis.

Results. In the hepatitis group, a moderate statistically significant relationship was found between BV and MTT (r = 0.5 p = 0.002), between MTT and the stiffness index according to UE (r = 0.6 p = 0.005). A similar correlation was observed between MTT and prothrombin time (r = 0.5 p = 0.04) and between MTT and total protein (r = 0.6 p = 0.009). In the group of patients with cirrhosis, correlations were found between BF and BV (r = 0.5 p = 0.01), between BF and total protein (r = 0.6 p = 0.0001), between BF and albumin (r = 0,6 p = 0.003) and between BF and GGTP (r = 0.5 p = 0.018).

Discussion. The statistical differences observed between BF and BV indirectly characterize the severity of fibrosis. In patients with hepatitis, the relationship between BV and MTT indicate the state of microcirculation, the relationship between MTT and total protein, between MTT and prothrombin time, reflect the effect of fibrosis on the indirect functional state of the liver.  In the group of patients with cirrhosis the correlation between BF and BV demonstrate the effect of fibrosis on the formation of impaired microcirculation.

Conclusion. The relationship between MTT and the stiffness index, between perfusion and clinical laboratory parameters indicates the possibility of assessing the functional state of the liver by means of PCT.

Siberian State Medical University. Tomsk, Russia.

 

 

Keywords: perfusion computed tomography, liver fibrosis, diffuse liver diseases, cirrhosis, hepatitis.

 


Corresponding author:  Mezikova E.A., e-mаil: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript

 

For citation: Mezikova E.A., Zavadovskaya V.D., Beloborodova E.V., Dolgalev I.V., Tonkih O.S., Rodionova O.V. Possibilities of perfusion computed tomography in diffuse liver diseases. REJR 2022; 12(1):56-66. DOI: 10.21569/2222-7415-2022-12-1-56-66.

Received:        30.01.21 Accepted:       23.12.21