Matrosova M.S., Bryukhov V.V., Belskaya G.N., Krotenkova M.V.


Research center of neurology. Moscow, Russia.



Purpose. To demonstrate the potential of T1 MP2RAGE pulse sequence in lesion assessment in the brain and spinal cord in patients with multiple sclerosis (MS).

Materials and methods. We present several patients with Multiple Sclerosis (MS) who underwent brain MRI on a Siemens Magnetom Prisma scanner (3 Tesla) using standard (T2, T2 FLAIR) and addi-tional (T1 MP2RAGE, DIR) pulse sequences to detect lesions of the main localization according to McDonald criteria.

Results. T1 MP2RAGE has good contrast and high resolution, hence it allows identify demye-lination lesions both in the cervical spinal cord, cerebellum and brainstem, and in the cortical gray matter in a single sequence.

Conclusion. The contrast of the T1 MP2RAGE sequence allows both detection of cortical, in-fratentorial and spinal lesions and simultaneous assessment of lesions in the brain and cervical spi-nal cord in a single pulse sequence, which can be used to reduce the scanning time. At the same time, it is possible to detect smaller cortical lesions using T1 MP2RAGE compared to DIR and detect lesions in the spinal cord, brainstem and chiasma missed at standard sequences.


Keywords: multiple sclerosis, magnetic resonance imaging, McDonald criteria, cortical lesions, spinal cord, T1 MP2RAGE.



Corresponding author: Matrosova M.S., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript


For citation: Matrosova M.S., Bryukhov V.V., Belskaya G.N., Krotenkova M.V. T1 MP2RAGE for brain and cervical spine lesions assessment in multiple sclerosis. REJR 2023; 13(1):87-95. DOI: 10.21569/2222-7415-2023-13-1-87-95.


Received: 25.12.22

Accepted: 24.01.23