NOVEL APPROACH FOR ASSESSING THE BLOOD FLOW OF GLIOMAS BASED ON 11C-METHIONINE PET-CT COMPARED TO CT PERFUSION AND ALS MR-PERFUSION STUDIES
Postnov A.A.1,2,3, Batalov A.I.1, Kalaeva D.B.1,2, Tyurina A.N.1, Zakharova N.E.1, Pronin I.N.1
1 - N.N. Burdenko National Medical Research Center of Neurosurgery.
2 - National Research Nuclear University MEPhI (Moscow Engineering Physics Institute).
3 - P. N. Lebedev Physical Institute of the Russian Academy of Sciences. Moscow, Russia.
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urpose. To analyze the possibility of using dynamic PET studies with 11C-methionine to assess the blood flow in gliomas in comparison with CT and ASL-MR perfusion methods currently used in clinic.
Materials and methods. Data from 9 patients were analyzed in whom brain tumor blood flow was measured by three independent methods. The size of the volume of interest was optimized, and a pairwise comparison of methods was carried out. The T/N index averaged over the first 60 seconds (T/N60) after administration of the radiopharmaceutical was chosen as a parameter that characterizes perfusion in PET-CT investigation.
Results. Comparison of T/N60 obtained from 11C-methionine PET studies showed a high and moderate correlation with ASL perfusion (R2 = 0.68) and CT perfusion (R2 = 0.48) respectively, provided the same VOIPET selected on PET studies was transferred to other modalities. The total uptake of methionine does not correlate with either CT or ASL perfusion.
Conclusion. This work shows that the value of the 11C-methionine T/N60index, measured in the first 60 seconds after the administration of a radiopharmaceutical, can serve as a good biomarker of tumor perfusion, along with CT and ASL perfusion methods.
Keywords: PET-CT with 11C-methionine, CT perfusion, ASL perfusion, glioma blood flow.
Corresponding author: Postnov A.A., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript
For citation: Postnov A.A., Batalov A.I., Kalaeva D.B., Tyurina A.N., Zakharova N.E., Pronin I.N. Novel approach for assessing the blood flow of gliomas based on 11C-methionine PET-CT compared to CT perfusion and ALS MR-perfusion studies. REJR 2023; 13(4):36-43. DOI: 10.21569/2222-7415-2023-13-4-36-43.
Received: 28.10.23 Accepted: 07.11.23