Tereshchenko G.V., Kriventsova N.A., Kuprianov D.A., Novichkova G.A.


Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. Moscow, Russia.


ixon MRI sequences based on chemical shift are highly sensitive to the fat and water content in the tissue. If special sequence as mDixon-quant is not available then it may be necessary to rely on a basic, and more generally available, method for FF measurement by fat-to-water ratio.

Purpose. To evaluate the comparability and reliability of the commonly used MRI program designed for wide practical use (mDixon) and the new program with fat fraction maps (mDixon-quant).

Materials and methods. The study included 100 patients under 18 years of age with aplastic anemia (64%) and chronic myeloproliferative disorders (36%). The study was carried out at the Dmit-


ry Rogachev haematology, oncology and immunology centre on the Philips Achieva 3.0 T using standard mDixon and mDixon-quant with FF maps. FF measured in the ilium and lumbar vertebrae.

Results. There was no statistically significant difference between FF by the water-to-fat ratio on mDixon and on mDixon-quant FF maps. In addition, both methods showed a strong correlation (r>0.996, p<0.001), high reliability (ICC>0.996).

Conclusion. The mDixon and mDixon-quant fat fraction values are comparable and can be used to evaluate bone marrow in paediatric patients with haematological disorders.


Keywords: acute coronary syndrome, depression, fMRI.


Corresponding author: Kriventsova N.A., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript


For citation: Tereshchenko G.V., Kriventsova N.A., Kuprianov D.A., Novichkova G.A. MRI of bone marrow fat fraction: Dixon vs Dixon-quant. REJR 2023; 13(4):92-100. DOI: 10.21569/2222-7415-2023-13-4-92-100.

Received:        07.07.23 Accepted:       07.11.23