РRENATAL US- AND MR-DIAGNOSTICS OF TWIN PREGNANCY WITH REGRESSIVE
COMPLETE HYDATIDIFORM MOLE AND A COEXISTING LIVE FETUS
Makogon A.V.1, Gornostaeva A.M.1,2, Korostyshevskaya A.M.2
1 – Clinical hospital «AVICENNA» Group of companies «Mother and child».
2 – Department of radiology, the Institute International Tomography Center of the Siberian Branch of the Russian Academy of Sciences. Novosibirsk, Russian Federation.
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urpose. A hydatidiform mole belongs to trophoblastic tumors and represents an abnormal pregnancy with embryonic development pathology due to genetic abnormalities. The coexistence of a complete hydatidiform mole and a normally developing fetus is a very rare pathology (1:20.000 – 1:250.000) that presents significant challenges in determining obstetric management due to high risks of complications for both fetus and mother.
Materials and methods. The article describes a clinical case of unique example of intrauterine verification of coexistence of a complete hydatidiform mole and a normally developing fetus using ultrasound (US) and magnetic resonance imaging (MRI), with a favorable outcome for fetus and mother. The full range of radiological prenatal diagnostic methods, biochemical markers, morphological, immunohistochemical and genetic technologies for diagnosis verification is demonstrated.
Results and Discussion. The presented clinical observation demonstrates that the coexistence of a hydatidiform mole and a normally developing fetus, although carrying high risks of complications, has a chance of a favorable outcome. Comprehensive examination allows for rational systematic monitoring, differential diagnosis and evidence-based prognosis of the outcome of such pregnancy.
Conclusion. This observation shows that timely radiological and laboratory diagnosis, systematic monitoring, enable predicting a favorable outcome and making the correct decision regarding the preservation of the pregnancy.
Keywords: twin pregnancy, hydatidiform mole, ultrasound, magnetic resonance imaging, prenatal diagnosis.
Corresponding author: Gornostaeva A.M., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript
For citation: Makogon A.V., Gornostaeva A.M., Korostyshevskaya A.M. A perinatal observation of twin pregnancy with regressive complete hydatidiform mole and a coexisting live fetus: case report and literature review. REJR 2024; 14(2):144-154. DOI: 10.21569/2222-7415-2024-14-2-144-154.
Received: 21.03.24 Accepted: 10.04.24