ULTRASOUND EXAMINATION OF RENAL GRAFT IN THE STUDY OF FACTORS AFFECTING ITS FUNCTIONAL STATE
Mukhametdinova L.M.1, Tukhbatullin M.G.1,2, Sitkina K.V.1
1 - Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan. Kazan, Russia.
2 - Kazan State Medical Academy – Branch Campus of the Russian Medical Academy of Continuous Professional Education. Kazan, Russia.
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urpose. To study the factors influencing the renal graft parenchyma stiffness indices.
Material and methods. The study included 50 patients with renal graft (RG) of the Kidney Transplant Department of the Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan aged 18 to 55 years, 5-7 days after surgery. Of these, 23 patients were male and 27 were female. The following factors that could potentially affect the RG parenchyma stiffness were studied: the resistance index (RI) indices in the arcuate and interlobular arteries of the RG, serum creatinine, age and gender of donors. Statistical analysis was performed using the StatTech v. 4.7.2 program (developer – StatTech LLC, Russia).
Results. A study of the relationship between the average resistance index in the arcuate and interlobular arteries and the parenchymal stiffness of the renal graft showed a direct but weak correlation. When assessing the relationship between the average RG parenchyma stiffness value and the serum creatinine index, a moderately strong direct relationship was found according to the Chaddock scale. When studying the relationship between parenchymal stiffness and donor age, a weak direct relationship was also found. With an increase in donor age by one year, the average value of renal graft parenchymal stiffness increased by 0.063 kPa. At the same time, the resulting model explains 8.3% of the observed variance of this indicator. Comparison of the average values of renal graft parenchymal stiffness depending on the donor's gender did not reveal statistically significant differences (p = 0.498).
Discussion. Shear wave elastography (SWE) is a non-invasive and safest method for examining a renal graft. When examining RI in the arcuate and interlobular arteries in correlation with the stiffness of the RG parenchyma, a weak direct relationship was found, where with an increase in the stiffness of the RG parenchyma, RI increases. In our study, when assessing the relationship between the average value of the parenchyma stiffness of the RG and serum creatinine, a moderately tight direct relationship was established, and with an increase in creatinine by 1 μmol / l, an increase in the average value of the parenchyma stiffness of the RG by 0.006 kPa should be expected. When studying the relationship between the average value of the parenchyma stiffness of the RG and the age of the donor, a weakly tight direct relationship was established. Thus, with an increase in the donor's age by 1 full year, an increase in the average value of the RG parenchyma stiffness by 0.063 kPa should be expected.
Conclusion. The parenchyma stiffness of the renal graft demonstrates a significant relationship with the resistance index in the arcuate and interlobular arteries and the level of serum creatinine. An increase in parenchyma stiffness is accompanied by an increase in these indicators, which reflects possible impairment of renal graft function. The use of shear wave ultrasound elastography allows an objective assessment of the condition of the renal graft, identifying signs of dysfunction and possible rejection. In combination with laboratory blood parameters, this method serves as an additional tool for predicting the functional state of the renal graft.
Keywords: renal graft, shear wave ultrasound elastography, resistance index.
Corresponding author: Mukhametdinova L.M., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript
For citation: Mukhametdinova L.M., Tukhbatullin M.G., Sitkina K.V. Ultrasound examination of renal graft in the study of factors affecting its functional state. REJR 2025; 15(3):211-220. DOI: 10.21569/2222-7415-2025-15-3-211-220.
Received: 03.04.25 Accepted: 30.10.25