SIMPLIFIED QUANTITATIVE ASSESSMENT OF INFLAMMATION INDEX (MaRIAs) IN
MAGNETIC RESONANCE ENTEROCOLONOGRAPHY IN CHILDREN WITH CROHN'S
DISEASE: ASSESSMENT OF COHERENCE WITH ENDOSCOPIC DATA
Khizhnikova V.V.1, Medvedeva N.A.1,2, Alieva E.I.1, Serova N.S.2
1 - Federal Research and Clinical Center for Children and Adolescents.
2 - I.M. Sechenov First Moscow State Medical University (Sechenov University). Russia, Moscow.
|
P |
urpose. To evaluate the correlation of magnetic resonance enterocolonography using the MaRIAs quantitative index and the SES-CD endoscopic scale in the segmental assessment of Crohn's disease activity in children.
Materials and methods. The retrospective study included 93 children aged 6 to 16 years with a histologically confirmed diagnosis of Crohn's disease. All children underwent ileocolonoscopy and MR-enterocolonography. The activity of the inflammatory process during MR-enterocolonography for each intestinal segment was determined using the MaRIAs index, and the endoscopic activity was assessed using the endoscopic assessment scale for Crohn's disease (SES-CD), with further comparison of the results.
Results. During ileocolonoscopy and magnetic resonance enterocolonography, 465 segments were examined. During magnetic resonance enterocolonography, changes in the intestinal wall were detected in 48 segments (10%): in 21 segments (5%), the changes were inflammatory (index value >1), and in 27 segments (6%), severe inflammation with the presence of ulcers was detected (index value >2). There were no changes in 417 segments (89%).
During ileocolonoscopy, changes were detected in 46 segments (10%): 20 segments (4%) had mild to moderate changes, and 26 segments (6%) had severe lesions. There were no changes in 419 segments (90%).
There is a strong relationship between the two scales according to the Spearman correlation coefficient (0.824).
Discussion. A number of domestic and foreign publications devoted to the study of the MaRIAs index also report high results of the consistency of this scale with the results of endoscopy. There are a number of difficulties in the application of MaRIAs, consisting in the definition of minimal inflammatory changes, as well as the detection of single ulcers. In the world practice, there are several different indices of the quantification of inflammatory changes and therapeutic response, demonstrating good results, which could be an excellent additional tool in routine practice in the examination and treatment of patients with Crohn's disease.
Conclusion. Magnetic resonance enterocolonography is an important non-invasive and safe method for assessing the prevalence and severity of the inflammatory process in the intestinal wall in children with Crohn's disease. The quantitative MaRIAs index demonstrated high coherence with ileocolonoscopy and can be used as an additional criterion for assessing the degree of inflammation in the intestinal wall, which is important for the dynamic monitoring of children during therapy and minimizing the number of endoscopic examinations under anesthesia.
Keywords: MR- enterography, MRI, Crohn's disease.
Corresponding author: Khizhnikova V.V., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript
For citation: Khizhnikova V.V., Medvedeva N.A., Alieva E.I., Serova N.S. Simplified quantitative assessment of inflammation index (MaRIAs) in magnetic resonance enterocolonography in children with crohn's disease: assessment of coherence with endoscopic data. REJR 2025; 15(4):119-126. DOI: 10.21569/2222-7415-2025-15-4-119-126.
Received: 13.05.25 Accepted: 11.12.25